Amphotericin-B Injection
Category: Anti Infectives
Each vial contains:
Amphotericin-B….. 50mg and 100mg
Quality Specification:
Chromatographic Purity: NLT 99.5%
Pack Size: vial

AMPHOTERICIN-B (AMB) It is active against a wide range of Yeasts and Fungi, Candida Albicams, Histoplasma Capsulation, Cryptococcus Neoformans, Blactomyces Dermatitides, Coccidioides, Inmates, Torulopsis, Rhodotorula, Aspergillus, Sporothrix etc. It is fungicidal at high and static at low concentrations.
 
Composition : 50mg, 100mg
Indication : Topically for oral, vaginal and cutaneous candidiasis and otomycosis. Most effective for various types of systemic mycoses. Intravenously for treatment of progressive and potential fatal fungal infections. Intestinal moniliasis.
Dosage : Orally-50-100mg four times.For Systemic mycoses, Initially 1 mg test dose is injected over 20 mins i.v. followed by 0.3 mg/kg body wt is infused over 4-8hrs. Max of 0.7 mg/kg body wt
Contra-Indications : Renal impairment, epilepsy.
Special Precautions : Test dose is must before giving intravenously. Adverse reactions can decrease with inclusion of hydrocortisone 0.6 mg/kg body wt in the Infusion
Paediatrics : Reduced dose may be necessary.
Pregnancy : No evidence of risk.
Lactation : No evidence of risk.
Elderly Safe :  
Side–effects : Chills, fever, aches, nausea,vomiting and dyspnoea. Thromboflebitis of the injected vein. (azotemia, reduced g.f.r, acidosis, hypokalemia and inability to concentrate urine). Anaemia due to bon marrow depression. C.N.S. toxicity.
Drug interactions : Potentiation of potassium loss by corticosteroids, increases digital toxicity, causes hypokalemia with diuretics, antagonism with ketoconazole, aminoglycosides enhance renal toxicity, induce toxicity enhanced in presence of other nephrotoxic agents.
Purity : Not less than 99%.
 
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