Omeprazole Injection
Omeprazole is a gastric proton pump inhibitors. This prodrug is a substituted benzimidazole derivative which acts on the final step of gastiric acid production and therefore controls acid secretion in response to all varieties of stimuli, omerprazole has prolonged action in a dose of 20-40mg once a day and reduces the 24 hours gastric acid output by almost 90%. It is highly effective in Zollinger-Ellison syndrome, recurrent duodenal ulcers & reflux oesophagitis. It also suppresses H-pylori. It should be taken before meals.
Composition : 20mg
Indications : Duodenal & gastric ulcers, NSAIDs induced ulcers, Zollinger-Ellison syndrome, reflux oesophagitis.
Contraindications : Hypersensitivity, pregnancy, lactation, children.
Safety Profile : Exclude the gastric malignancy, renal & hepatic dysfunction, epilepsy, avoid its use with alcohol.
Adverse Effects : Skin rashes, abdominal colic, diarrhoea, nausea, dry mouth, dizziness, headache, constipation & flatulence, increased risk of enteric infections due to reduced acid secretion.
Drug Interactions : Diazepam, phenytoin, warfarin, cyclosporine & digoxin.
Dosage: Peptic ulcers - 20mg once daily for 4 weeks max up to 8 weeks.
Reflux oesophagitis-20-40mg once daily for 4-8 weeks.
Z.E.S. - 60mg once daily to start than 20-120mg daily in 2 divided dose.
Purity : Not less than 99%.
 
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