Mitomycin Injection
It is an antibiotic isolated from streptomyces caespitosis, It selectively inhibits synthesis of DNA.

Composition : 2mg, 10mg & 40mg
Indications : Disseminated adenocarcinoma of stomach and pancreas.
Contraindications : Patients with previous idiosyncratic reaction to the drug, patient with thrombocytopenia, coagulation disorders, increase in bleeding tendency, pregnancy etc.
Adverse Effects : Fever, anorexia, nausea, vomiting, bone marrow, depression (within 8 weeks of onset of therapy) etc. Cellulitis at injection site, stomatitis, alopecia, renal impairment, pulmonary toxicity, haemolytic uraemia syndrome (micro angiopathic haemolytic anaemia, thrombocytopenia, irreversible, renal failure), congestive heart failure, headache, visual blurring, diarrhoea, pain etc.
Drug Interactions : Potentiates adriamycin induced cardiotoxicity. Barbiturates alter levels. Synergestic with 5-flurouracil.
Dosage : 20 mg/m² i.v. single dose via ½ catheter. Patient should be fully evaluated after each course and dose decrease if toxicity appears.
Purity : Not less than 99%
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